I have migrated to Debian 10 recently and opted for netinstall.
I have two old computers that I repurposed as backup PC's which I am currently using.
PC Phenom
Phenom X4 9750 - DDR2 2GB - Nvidia 8200
PC Athlon
Athlon II X2 250 - DDR3 2GB - Gigabyte 210 Rev 5.0
I decided to make a Debian 10 installation for my Athlon PC by using my Phenom PC since my Athlon PC had a broken PSU that couldn't supply 12V through Molex/SATA power lines and I just didn't trust my USB 3.0 SATA adapter with a PC with an allready messed up PSU.
So I decided to connect my new HDD to the Phenom PC and install Debian 10 there. I successfully installed Debian 10 with XFCE using nonfree netinst cd but I am curious if it will work. When I used SparkyLinux with the Phenom PC lots of time ago. I kept getting "Couldn't find processor microcode" errors whenever I used apt and I am afraid of the same and similar things happening with this "Cross Installation". I couldn't even connect my new HDD to the Athlon PC since I did the installation and I am far from home and thus couldn't test my installation yet.
So In the end, Does "Cross Installing" Debian 10 make sense?