Kernel documentation proved to be helpful. This page exactly: https://www.kernel.org/doc/Documentation/vm/transhuge.txt
Transparent Hugepage Support for anonymous memory can be entirely disabled (mostly for debugging purposes) or only enabled inside MADV_HUGEPAGE regions (to avoid the risk of consuming more memory resources) or enabled system wide. This can be achieved with one of:
echo always > /sys/kernel/mm/transparent_hugepage/enabled
echo madvise > /kernel/mm/transparent_hugepage/enabled
echo never > /sys/kernel/mm/transparent_hugepage/enabled
And few paragraphs below.
khugepaged will be automatically started when transparent_hugepage/enabled is set to "always" or "madvise, and it'll be automatically shutdown if it's set to "never".
There is no concrete information about impact on /sys/kernel/mm/transparent_hugepage/defrag option. Yet, since they said that setting option /sys/kernel/mm/transparent_hugepage/enabled to never will entirely disable THP, I can only assume that - indeed - it's safe to ignore other options, as they won't have any impact on disabled feature.