I just started Firefox on my Gentoo machine upon which it crashed with
ATTENTION: default value of option force_s3tc_enable overridden by environment.
Now, a bit of research gave me nothing tangible but the vague impression that the root cause of this is somewhere close to graphics and mesa. Indeed, greping everything for force_s3tc_enable hit a few shared object files under /usr/lib/mesa/. My impression was further reinforced by this posting.
Anyway, whenever I launch Firefox, it (a) crashes immediately or (b) offers me (b1) to start in safe browsing mode (which works) or (b2) to clean up firefox (which crashes). (a) and (b) alternate perfectly. Setting an environment variable with the name force_s3tc_enable (obvious choices were true and false) has no noticeable effect whatsoever. I remember that I had a similar problem with Google Chrome a while ago but somehow it went mysteriously away, I don't recall any details.
So... what is the cause for the problem and how can I fix it?
Details of the installation
The system is running in a VMware virtual machine where I use the VMware video driver. Mesa is mesa-12.0.1 and Firefox is firefox-45.4.0. (Further details available on request, I don't want to dump the entire emerge --info output here without need.)